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After taking account of the extent of existing cardiovascular depression and disease these risks disappeared. This was found from searching at the prescription data before and following the heart attack. The conclusion arrived at was that any elevated coronary attack risk is more likely to become from the underlying depression as opposed to the drugs themselves. The authors also didn’t find any hyperlink with specific antidepressants or with the class of drug.. Antidepressants not the culprit in depression linked to heart attacks The increased threat of heart attack associated with taking antidepressants may be due to the depression itself rather than the medicines themselves, suggests new research reported in the current issue in the British Medical Journal.